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Invitris




Manufacturing Bacteriophages for Precision Medicine

Pathogenic Bacteria Turn Drug-Resistant at an Alarming Rate. While efforts to develop novel antimicrobial compounds have increased in recent years, there is still a lack of safe and effective substitutes for antibiotics.
But there is a promising alternative

-Bacteriophages-

Phages Are the Natural Enemies of Bacteria
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Phages are capable of specifically and reliably infecting and killing bacteria but are harmless to human cells. They can therefore be administered to patients as a cure for bacterial infections. This process is called:



Phage Therapy







but...
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Traditional Methods

...are unsafe for manufacturer and patient. Giant flasks of pathogenic bacteria are cultivated in order to isolate therapeutic bacteriophages.

How does Invitris work?
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Modular Phage Assembly

With a cell-free production system we utilize one of the most revolutionary concepts of synthetic biology to produce therapeutic bacteriophages. Based on personalized diagnostics, bacteriophage DNA is chosen from a library and subjected to extensive quality assessment procedures to ensure a safe and effective application.

homogeneous

Because our raw material is DNA, phage therapy based on well-defined phages is no longer a fantasy.

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software-aided

State of the art DNA sequencing tools are combined with bioinformatics to precisely determine the amount of contaminants in a sample.

high quality

The phage genome DNA is extensively purified, resulting in a high quality template with minimal contamination.

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Synthetic Phage Manufacturing

Production of bacteriophages in a cell-free system ensures a fast and reliable application. Furthermore, working in a cell-free environment enables host independent production of phages in only 2.5% of the conventional production volume while demanding no biosafety regulations.

affordable

At less than $10 per treatment, Phactory allows for a highly competitive production price.

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scalable

Manufacturing in Phactory can be scaled up for bulk production.

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modular

Phactory is an open system. This allows for the incorporation of modified proteins while leaving the genome unmodified, thereby achieving modularity without genetic modifications.

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safe

Host independence eliminates the need to cultivate pathogens to produce bacteriophages.


Quality Control

A thorough quality control structure assures that the produced bacteriophages are pure and effective. Risk of toxic contamination is eliminated.

pure

Purity is essential for any therapeutic application. We use third generation sequencing to guarantee absence of DNA contamination in the manufacturing process.

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toxin-free

Phactory assembles phages outside of living cells and is therefore free of most biological contaminants. We engineered the manufacturing system to reduce immunogenicity in humans by several orders of magnitude.

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GMO-free

The phages assembled by Phactory are purified to remove any genetically modified material before leaving a controlled lab environment.

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Packaging

Bacteriophage therapy covers a broad range of potential applications. We engineered custom hardware to package bacteriophages for oral treatment. Our packaging procedure is the last step of a personalized on-site manufacturing process.

long shelf-life

Phactory and phages are fragile components. We combined various techniques to enable phage assembly outside of a lab.

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portable

We demonstrated lyophilization of Phactory components in order to enable long range transport.

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on-site

Producing phages in Phactory is so simple that it allows any doctor to apply phage therapy on-site.


Therapy

Our bacteriophages are now ready for therapy. Phactory is fast and reliable enough to be an oral bedside application.

ready

In cooperation with phage therapy pioneers in Belgium, we safely produced functional phages against EHEC – a deadly pathogen.

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